Effect of acid extraction on the osteogenic activity of bone tissue

Rat bones demineralized in HCl and TCA exhibited distinct osteoinductive activity while the bones demineralized using EDTA did not show the activity. HCl- and TCA-extracts of bones differed from EDTA extracts by chromatographic and radiochromatographic profiles. At the same time, HCl- and TCA-extrac...

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Bibliographic Details
Published inVoprosy meditsinskoi khimii Vol. 33; no. 1; p. 51
Main Author Sumarokov, D D
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.1987
Subjects
Animals
Bone Matrix - analysis
Bone Matrix - physiology
Bone Regeneration
Bone Transplantation
Edetic Acid
Hydrochloric Acid
Minerals - analysis
Rats
Tissue Extracts - analysis
Trichloroacetic Acid
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Summary:Rat bones demineralized in HCl and TCA exhibited distinct osteoinductive activity while the bones demineralized using EDTA did not show the activity. HCl- and TCA-extracts of bones differed from EDTA extracts by chromatographic and radiochromatographic profiles. At the same time, HCl- and TCA-extracts contained additional fraction. The substances involved in the fraction appear to be responsible for inhibition of the osteoinductive factor of bone tissue.
ISSN:0042-8809