Genetic variants of acid erythrocytic phosphatase as a risk factor of rheumatic fever

• Published in: Terapevtic̆eskii arhiv Vol. 61; no. 5; p. 73
• Main Authors: Krylov, M Iu, Belov, B S, Miakotkin, V A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 1989
• Subjects: Acid Phosphatase - blood; Acid Phosphatase - genetics; Adolescent; Adult; Arthritis - blood; Arthritis - enzymology; Arthritis - genetics; Erythrocytes - enzymology; Female; Humans; Isoenzymes - blood; Isoenzymes - genetics; Male; Middle Aged; Phenotype; Rheumatic Fever - blood; Rheumatic Fever - enzymology; Rheumatic Fever - genetics; Risk Factors
• ISSN: 0040-3660

A study was made of the genetic variants (isoenzymes, phenotypes) of acid erythrocytic phosphatase (AcP) in 120 patients with rheumatic fever. There were 78 women and 42 men aged 16 to 57 years. The population data concerned with distribution of the AcP variants among the population of Moscow were used as control. As compared with control, the patients suffering from rheumatic fever demonstrated the accumulation of the rarely occurring variants of AcP (AC, BC and CC, in particular). A significant direct correlation was established between the activity of isoenzymes and relative risk of rheumatic fever incidence. The definite regularities in the distribution of AcP variants were found to depend on the disease clinical patterns (the articular syndrome, the times of the formation of heart diseases, the character of recurrent rheumocarditis). The data obtained can used for distinguishing the rheumatic fever risk groups and forecasting the rheumatic process (to a certain degree of probability).