T- and B-components of immunity in acute altitude sickness

Immunological aspects of the adaptation process were investigated in 57 male test subjects that stayed for 30 days at an altitude of 3600 m above sea level (Eastern Pamir Mountain Range). The uneventful development of adaptation was accompanied by a short-term decrease in the number and activity of...

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Bibliographic Details
Published inKosmicheskaia biologiia i aviakosmicheskaia meditsina Vol. 20; no. 1; p. 53
Main Authors Mirrakhimov, M M, Kitaev, M I, Khamzamulin, R O, Tokhtabaev, A G, Pogrebitskiĭ, S M
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.1986
Subjects
Acclimatization
Acute Disease
Altitude Sickness - immunology
B-Lymphocytes - immunology
Cell Separation
Concanavalin A - pharmacology
Humans
Hypoxia - immunology
Leukocyte Count
Lymphocyte Activation
Male
Phytohemagglutinins - pharmacology
Rosette Formation
T-Lymphocytes - immunology
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Summary:Immunological aspects of the adaptation process were investigated in 57 male test subjects that stayed for 30 days at an altitude of 3600 m above sea level (Eastern Pamir Mountain Range). The uneventful development of adaptation was accompanied by a short-term decrease in the number and activity of T-lymphocytes. An acute mountain disease led to a distinct deficiency of T-cell immunity which still persisted on test day 30. Besides, the content of zero cells in circulating blood was increased and the blast-transformation reaction of lymphocytes to concanavalin A was inhibited. Prior to the ascent the test subjects who were susceptible to the acute mountain disease showed a lower content of T-lymphocytes and a higher content of zero cells in circulating blood.
ISSN:0321-5040