Studies of animal experiment models of the behavior of the glomerular filtration rate in acute changes of dietary protein consumption

The glomerular filtration rate (GFR) and the tubulo-secretoric transport maximum of para-aminohippuric acid (TmPAH) were examined in acute feeding trials (pellets, flesh) and after infusion of furesemide, dopamin and glucagon in normal and unilaterally nephrectomized Wistar rats. The aim of the stud...

Full description

Saved in:
Bibliographic Details
Published inZeitschrift fur Urologie und Nephrologie Vol. 82; no. 2; p. 93
Main Authors Wüstenberg, P W, Chol, H, Schröder, J, Nitschke, F P, Klinkmann, H
Format Journal Article
LanguageGerman
Published Germany 01.02.1989
Subjects
Animals
Dietary Proteins - administration & dosage
Dopamine - pharmacology
Dose-Response Relationship, Drug
Female
Furosemide - pharmacology
Glomerular Filtration Rate - drug effects
Glucagon - pharmacology
Infusions, Intravenous
Kidney Tubules - metabolism
Nephrectomy
p-Aminohippuric Acid - pharmacokinetics
Rats
Online AccessGet more information

Cover

More Information
Summary:The glomerular filtration rate (GFR) and the tubulo-secretoric transport maximum of para-aminohippuric acid (TmPAH) were examined in acute feeding trials (pellets, flesh) and after infusion of furesemide, dopamin and glucagon in normal and unilaterally nephrectomized Wistar rats. The aim of the study was to investigate the start process of GFR rise in a further experimental model (apart from the hyperfiltration in residual nephrons) and to confirm the so-called paradoxical GFR changes. The investigations of acute protein-loading induced GFR changes were without results, whereas a GFR rise could observed during intraarterial infusion of isotonic saline solution. A paradoxical GFR behaviour was demonstrable under high glucagon application.
ISSN:0044-3611