The effect of proxodolol on systemic and regional hemodynamics

The effect of the new hybrid (beta-, alpha-) adrenoceptor blocking drug proxodolol on cardiac output and its distribution between 16 vascular regions, by using the microsphere method on anesthesized normotensive rats and rats with persistent renovascular hypertension. Proxodolol given in beta-adreno...

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Bibliographic Details
Published inĖksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 57; no. 3; p. 33
Main Authors Dolgun, O V, Martynova, E R, Medvedev, O S, Iuzhakov, S D
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1994
Subjects
Adrenergic alpha-Antagonists - pharmacology
Adrenergic alpha-Antagonists - therapeutic use
Adrenergic beta-Antagonists - pharmacology
Adrenergic beta-Antagonists - therapeutic use
Animals
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Hemodynamics - drug effects
Hypertension, Renovascular - drug therapy
Hypertension, Renovascular - physiopathology
Labetalol - pharmacology
Labetalol - therapeutic use
Male
Microspheres
Oxadiazoles - pharmacology
Oxadiazoles - therapeutic use
Rats
Vasodilator Agents - pharmacology
Vasodilator Agents - therapeutic use
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Summary:The effect of the new hybrid (beta-, alpha-) adrenoceptor blocking drug proxodolol on cardiac output and its distribution between 16 vascular regions, by using the microsphere method on anesthesized normotensive rats and rats with persistent renovascular hypertension. Proxodolol given in beta-adreno-blocking doses similar to those of labetalol was shown to exert vasodilating effects in normotensive rats. Renal, adrenal, splenic, and skeletal muscle vessels were most sensitive to labetalol, whereas cardiac and pulmonary vessels were responsive to proxodolol. In rats with persistent renovascular hypertension, proxodolol had a vasodilating effect only when it was used in doses inducing alpha-adrenoceptor blockade.
ISSN:0869-2092