HbC/beta-thalassemia association. Eleven cases observed in Tunisia

Eleven cases of simultaneous HbC hemoglobinopathy and beta-thalassemia were detected during a study of 11,200 subjects at high risk for inherited hemoglobin anomalies. In seven cases, main clinical manifestations were anemia and enlargement of the spleen, whereas the four other patients were apparen...

Full description

Saved in:
Bibliographic Details
Published inAnnales de pediatrie Vol. 40; no. 1; p. 45
Main Authors Fattoum, S, Guemira, F, Abdennebi, M, Ben Abdeladhim, A
Format Journal Article
LanguageFrench
Published France 01.01.1993
Subjects
Adolescent
Adult
beta-Thalassemia - blood
beta-Thalassemia - complications
beta-Thalassemia - epidemiology
Child
Child, Preschool
Comorbidity
Female
Hemoglobin C Disease - blood
Hemoglobin C Disease - complications
Hemoglobin C Disease - epidemiology
Humans
Incidence
Male
Mass Screening
Risk Factors
Tunisia - epidemiology
Tunisia
Online AccessGet more information

Cover

More Information
Summary:Eleven cases of simultaneous HbC hemoglobinopathy and beta-thalassemia were detected during a study of 11,200 subjects at high risk for inherited hemoglobin anomalies. In seven cases, main clinical manifestations were anemia and enlargement of the spleen, whereas the four other patients were apparently free of symptoms and were diagnosed during routine tests in family members of affected patients. Microcytosis and hypochromia were found in every case. Most of the patients were from the North-Western part of Tunisia. Blood transfusions were required in only one patient, who was an infant with HbC/beta + thalassemia.
ISSN:0066-2097