Myopathy associated with infection by the human immunodeficiency virus type-1 (HIV-1)

• Published in: Anales de medicina interna (Madrid, Spain : 1984) Vol. 9; no. 11; p. 557
• Main Authors: Gabriel Botella, F, Rosello Sastre, E, Labios Gómez, M, Carda Batalla, C, Balaguer Martínez, J V, Arnal Babiloni, M
• Format: Journal Article
• Language: Spanish
• Published: Spain 01.11.1992
• Subjects: Acquired Immunodeficiency Syndrome - complications; Acquired Immunodeficiency Syndrome - diagnosis; Acquired Immunodeficiency Syndrome - pathology; AIDS-Related Opportunistic Infections - complications; AIDS-Related Opportunistic Infections - diagnosis; AIDS-Related Opportunistic Infections - pathology; Biopsy; HIV Antibodies - blood; HIV-1; Humans; Lung - pathology; Male; Middle Aged; Muscles - ultrastructure; Muscular Diseases - complications; Muscular Diseases - diagnosis; Muscular Diseases - pathology; Pneumonia, Pneumocystis - complications; Pneumonia, Pneumocystis - diagnosis; Pneumonia, Pneumocystis - pathology
• ISSN: 0212-7199

We present a case of an active homosexual patient who was a paid donor of plasma and presented myopathy associated to infection by the human immunodeficiency virus type 1 (HIV-1). In the ultrastructural study of the muscular biopsy, we stress the formation of central intermyofibrillary "minocores", as well as the presence of nuclear extrusions in which the core is surrounded by mitochondrial accumulations. We review the clinical, histological and ultrastructural characteristics used to identity this pathology against the group of myopathies induced by zidovudine, as well as the several empirical therapies currently recommended.