Effect of an antiserum to brain gamma gamma-enolase (protein 14-3-2) on ethanol consumption by rats

The influence of intracisternal administration of antiserum to the neurospecific brain gamma gamma-enolase (aS-gamma gamma) on the consumption of 7.5% ethanol solution by rats was studied. Injection of aS-gamma gamma decreased the ethanol intake by the rats which had been drinking 15% solution of et...

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Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 107; no. 2; p. 196
Main Authors Usatenko, M S, Shabanov, P D, Matveeva, I M, Kalishevich, S Iu, Borodkin, Iu S
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.02.1989
Subjects
Alcohol Drinking - drug effects
Animals
Brain - enzymology
Brain - immunology
Cisterna Magna
Drinking - drug effects
Immune Sera - administration & dosage
Immune Sera - pharmacology
Immunization - methods
Phosphopyruvate Hydratase - analysis
Phosphopyruvate Hydratase - immunology
Rabbits
Rats
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Summary:The influence of intracisternal administration of antiserum to the neurospecific brain gamma gamma-enolase (aS-gamma gamma) on the consumption of 7.5% ethanol solution by rats was studied. Injection of aS-gamma gamma decreased the ethanol intake by the rats which had been drinking 15% solution of ethanol for 7 months as a single source of liquid. In vitro aS-gamma gamma caused 4-fold inhibition of the gamma gamma-enolase activity while it did not influence the alpha alpha-enolase activity. Intracisternal administration of aS-gamma gamma shifted enolase isoenzyme spectra in the direction of the decrease of gamma gamma-enolase content. It is suggested that the effect of aS-gamma gamma on ethanol consumption is due to inhibition of the activity of gamma gamma-enolase which participates in energy metabolism in neurons.
ISSN:0365-9615