An experimental study of the immunogenic and protective properties of Coxiella burnetii strain M-44 and a live enteral vaccine against Q fever

High effectiveness of C.burnetii strain M-44 was confirmed in experimental studies on subcutaneously immunized guinea pigs ¿correction of pig] after their intratracheal infection with the virulent culture of the infective agent. The study revealed that the dose necessary for the enteral immunization...

Full description

Saved in:
Bibliographic Details
Published inŽurnal mikrobiologii, ėpidemiologii i immunobiologii no. 1; p. 38
Main Authors Mikhaĭlov, V V, Vorob'ev, A A, Makhlaĭ, A A, Khaltaeva, G G, Suvorova, T A, Krasnianskiĭ, V P, Iakovlev, E A, Pashanin, Iu G, Dykanov, G A, Podkuĭko, V N, Lebedinskaia, E V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.1996
Subjects
Animals
Coxiella burnetii - immunology
Coxiella burnetii - pathogenicity
Dose-Response Relationship, Immunologic
Guinea Pigs
Immunization - methods
Macaca fascicularis
Papio
Q Fever - immunology
Q Fever - prevention & control
Rats
Rickettsial Vaccines - immunology
Vaccines, Attenuated - immunology
Virulence
Online AccessGet more information

Cover

More Information
Summary:High effectiveness of C.burnetii strain M-44 was confirmed in experimental studies on subcutaneously immunized guinea pigs ¿correction of pig] after their intratracheal infection with the virulent culture of the infective agent. The study revealed that the dose necessary for the enteral immunization of guinea pigs and monkeys was 10(4.8) -- 10(5.0) times less than that needed for the oral immunization of the animals. Live enteral vaccine obtained on the basis of this strain possessed sufficiently pronounced immunogenic and protective properties, protecting 75% of immunized monkeys from subcutaneous infection with C.burnetii virulent culture.
ISSN:0372-9311