Effect of synthetic fragments of thymic peptide hormones on learning and memory processes

Seven synthetic peptide fragments of thymic hormones were investigated using behavioral and electrophysiological methods. Splenopentin was shown to increase markedly learning capacities and memory. In contrast, alpha 1-thymosin fragment decreased them. Other peptides only slightly affected the capac...

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Bibliographic Details
Published inFiziologicheskii zhurnal SSSR imeni I. M. Sechenova Vol. 74; no. 5; p. 634
Main Authors Martynov, V F, Leont'eva, L I, Sorochinskaia, E I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1988
Subjects
Animals
Conditioning, Classical - drug effects
Conditioning, Classical - physiology
Dose-Response Relationship, Drug
Electroencephalography
Female
Hormones - pharmacology
Learning - drug effects
Learning - physiology
Male
Memory - drug effects
Memory - physiology
Peptide Fragments - pharmacology
Rabbits
Rats
Social Behavior
Thymus Hormones - pharmacology
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Summary:Seven synthetic peptide fragments of thymic hormones were investigated using behavioral and electrophysiological methods. Splenopentin was shown to increase markedly learning capacities and memory. In contrast, alpha 1-thymosin fragment decreased them. Other peptides only slightly affected the capacities. Two active peptides seem to affect the level of activation of subcortical structures responsible for the excitation and inhibition.
ISSN:0015-329X