Albofungin formation by a strain isolated as a result of fusion of protoplasts of organisms producing aminoglycoside antibiotics

Strain 344 synthesizing an antibiotic complex was isolated after fusion of the protoplasts of Streptomyces monomycini producing monomycin and Streptomyces kanamyceticus producing kanamycin. The major component of the complex was identified with albofungin and the minor one was suggested to be chlora...

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Bibliographic Details
Published inAntibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] Vol. 36; no. 5; p. 5
Main Authors Malanicheva, I A, Koz'mian, L I, Dudnik, Iu V, Novozhenov, M Iu, Laĭko, A V, Potapova, N P
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1991
Subjects
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - metabolism
Cell Fusion
Erythromycin Ethylsuccinate - metabolism
Isoquinolines - metabolism
Kanamycin - metabolism
Molecular Structure
Protoplasts - cytology
Protoplasts - metabolism
Streptomyces - metabolism
Xanthenes - metabolism
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Summary:Strain 344 synthesizing an antibiotic complex was isolated after fusion of the protoplasts of Streptomyces monomycini producing monomycin and Streptomyces kanamyceticus producing kanamycin. The major component of the complex was identified with albofungin and the minor one was suggested to be chloralbofungin. In the cultures of strain 344 variants forming monomycin were detected. After regeneration of the protoplasts of the parent strains there were isolated no stable clones synthesizing antibiotics differing from monomycin and kanamycin.
ISSN:0235-2990