Laboratory data on the experimental transmission of Creutzfeldt--Jakob disease in the guinea pig

Cerebrospinal fluid samples collected from 3 patients with Creutzfeldt-Jakob disease were inoculated intracerebrally to guinea pigs. After an incubation period of 4-14 months the animals developed a serially transmissible disease, characterized by loss of appetite, loss of weight, difficulty in move...

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Published inVirologie Vol. 32; no. 3; p. 207
Main Authors Drăgănescu, N, Gîrjabu, E, Petrescu, A, Anghelescu, N, Mărcuţiu, V, Ionescu, M, Antipa, C
Format Journal Article
LanguageEnglish
Published Romania 01.07.1981
Subjects
Animals
Brain - pathology
Cerebral Cortex - pathology
Creutzfeldt-Jakob Syndrome - pathology
Creutzfeldt-Jakob Syndrome - transmission
Dendrites - pathology
Disease Models, Animal
Guinea Pigs
Humans
Neuroglia - pathology
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Summary:Cerebrospinal fluid samples collected from 3 patients with Creutzfeldt-Jakob disease were inoculated intracerebrally to guinea pigs. After an incubation period of 4-14 months the animals developed a serially transmissible disease, characterized by loss of appetite, loss of weight, difficulty in movement, myoclonic convulsions and a fatal outcome within several days. The microscopic lesions caused by the experimental disease consisted in glial proliferation, spongiform change and vacuolation of the cytoplasm of proximal dendritic regions.
ISSN:0253-181X