The effect of the one-time and long-term administration of preparations acting on biogenic amine metabolism on the blood level of pressor peptide hormones

• Published in: Likars'ka sprava no. 9; pp. 78 - 81
• Main Authors: Rudichenko, V M, Komissarenko, I V, Slavnov, V N, Markov, V V, Oleĭnik, V A
• Format: Journal Article
• Language: Russian
• Published: Ukraine 01.09.1993
• Subjects: Adolescent; Adult; Angiotensin II - blood; Biogenic Amines - blood; Blood Pressure - drug effects; Bromocriptine - administration & dosage; Chronic Disease; Cyproheptadine - administration & dosage; Drug Evaluation; Female; Humans; Hypertension - blood; Hypertension - drug therapy; Hypothalamic Diseases - blood; Hypothalamic Diseases - drug therapy; Male; Middle Aged; Syndrome; Time Factors; Vasopressins - blood
• ISSN: 1019-5297

Blood contents of pressor peptide hormones vasopressin and angiotonin II were studied in patients with neuro-endocrine syndrome before and after single intake and prolonged treatment with anti-serotonin drug peritol and cholinergic agent parlodel which affect biogenic amine metabolism and, consequently, influence blood pressure. Single doses of the drugs were established to cause different blood dynamics of vasopressin and angiotonin II which classified as marked and paradoxic reactions on peritol and parlodel used separately and associatively. Fall of blood vasopressin content induced by single dose of parlodel was accompanied by blood pressure decrease. Tree-week treatment with peritol and parlodel exerted hypotensive effect and significantly reduced vasopressin blood content.