Patho- and morphogenesis of infectious myocarditis

An experimental study in white mice infected with influenza virus A1, staphylococcus, Pseudomonas aeruginosa, Escherichia coli or Proteus, showed toxic vascular, stromal and cardiomyocyte damage in the myocardium within the first 2-3 days (circulation disorders, edema, dystrophic and necrotic change...

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Bibliographic Details
Published inKardiologiia Vol. 23; no. 10; p. 28
Main Authors Maksimov, V A, Baliabin, A A, Dygin, V P, Liashenko, Iu I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.10.1983
Subjects
Animals
Antibodies - analysis
Antigens - analysis
Humans
Infection - complications
Infection - immunology
Infection - pathology
Mice
Myocarditis - etiology
Myocarditis - immunology
Myocarditis - pathology
Myocardium - pathology
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Summary:An experimental study in white mice infected with influenza virus A1, staphylococcus, Pseudomonas aeruginosa, Escherichia coli or Proteus, showed toxic vascular, stromal and cardiomyocyte damage in the myocardium within the first 2-3 days (circulation disorders, edema, dystrophic and necrotic changes in cardiomyocytes), which by day 3-5 were replaced by inflammation resulting in the formation of myocarditic cardiosclerosis foci by the 3d-4th week. Certain immune disorders were detected in patients with infectious myocarditis; cardiac antigen was found in the serum of 24%, anticardiac antibodies in 22%, positive blast transformation tests in 7.5%, as well as reduced quantities of T cells. Coons's method at late dates after staphylococcal angina revealed antibodies to myocardial structures in 45.7% of patients, and those to connective tissue in 36.1-31.4%. Myocarditis signs were identified in part of those. A scheme is proposed for the pathogenesis of infectious myocarditis.
ISSN:0022-9040