A behavioral and biochemical analysis of the therapeutic effect of sodium oxybutyrate in alcoholic encephalopathy in progeny

The alcoholization of pregnant female rats (5 g/kg) results in a decrease of endogenous ethanol level in their offspring and distant disturbances of the conditioned reflex activities of the young rats deteriorating the formation and preservation of the skill with an emotional positive reinforcement....

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Published inFarmakologiia i toksikologiia Vol. 54; no. 1; p. 62
Main Authors Trofimov, S S, Ostrovskaia, R U, Smol'nikova, N M, Nemova, E P, Bobrova, O V, Koltovaia, N A, Ushakov, A N, Tsirenina, M L
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.1991
Subjects
Alcoholism - drug therapy
Alcoholism - metabolism
Animals
Behavior, Animal - drug effects
Biogenic Amines - metabolism
Brain - drug effects
Brain - metabolism
Brain Diseases - chemically induced
Brain Diseases - drug therapy
Brain Diseases - metabolism
Drug Evaluation, Preclinical
Ethanol - toxicity
Female
Learning - drug effects
Lipid Metabolism
Memory - drug effects
Pregnancy
Prenatal Exposure Delayed Effects
Rats
Sodium Oxybate - therapeutic use
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Summary:The alcoholization of pregnant female rats (5 g/kg) results in a decrease of endogenous ethanol level in their offspring and distant disturbances of the conditioned reflex activities of the young rats deteriorating the formation and preservation of the skill with an emotional positive reinforcement. Sodium gamma-gydroxybutyrate administered in a dose of 50 mg/kg from the 8th to the 20th day of life prevents the above-mentioned disturbances of learning and memory, restores the level of endogenous ethanol, corrects the parameters of lipid and mediator metabolism in the brain and blood changed by prenatal alcoholization.
ISSN:0014-8318