Treatment of bone infections with gentamicin-containing acrylic cement beads. Prognostic value of the study of the suction drainage fluid

Treatment of bone infections with gentamicin-PMMA beads is an adjunct to conventional surgery. Early failures occurred in a number of cases, due to technical problems, such as incomplete debridement, residual alloplastic material, or gentamicin-resistant pathogens. To evaluate short term results of...

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Bibliographic Details
Published inPathologie biologie (Paris) Vol. 32; no. 5; p. 455
Main Authors Borderon, E, Sillion, D, Delplace, J, Klifa, G
Format Journal Article
LanguageFrench
Published France 01.05.1984
Subjects
Adult
Aged
Drug Implants
Female
Gentamicins - administration & dosage
Gentamicins - therapeutic use
Humans
Male
Methylmethacrylates
Middle Aged
Orthopedics
Osteitis - drug therapy
Prognosis
Time Factors
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Summary:Treatment of bone infections with gentamicin-PMMA beads is an adjunct to conventional surgery. Early failures occurred in a number of cases, due to technical problems, such as incomplete debridement, residual alloplastic material, or gentamicin-resistant pathogens. To evaluate short term results of the method, clinical and bacteriological pre-therapy data were compared with results obtained two and six weeks after surgery, in 25 patients. Gentamicin concentrations, gentamicin levels/MBC for gentamicin, and bactericidal activity in secretions collected from suction drainage were not correlated with outcome. Cultures from the drains were the best parameters: cultures remained positive throughout follow-up in patient with poor clinical results.
ISSN:0369-8114