Characteristics of hematopoietic system reactions of newborn and adult mice to the growth of syngeneic hepatoma H-2-73

The growth of syngeneic hepatoma H-2-73 in adult (CBA x C57BL/6j) F1 mice leads to the development of leukemoid response that is manifested by leukocytosis, splenomegaly and a considerable increase in the content of lymphoid cells in the spleen. Meanwhile the newborn recipients of the tumor do not d...

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Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 93; no. 6; p. 90
Main Authors Chertkova, A I, Belianchikova, N I, Bukhman, V M
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.06.1982
Subjects
Animals
Animals, Newborn
Female
Hematopoietic System - physiopathology
Liver Neoplasms, Experimental - physiopathology
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Neoplasm Transplantation
Spleen - physiopathology
Transplantation, Isogeneic
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Summary:The growth of syngeneic hepatoma H-2-73 in adult (CBA x C57BL/6j) F1 mice leads to the development of leukemoid response that is manifested by leukocytosis, splenomegaly and a considerable increase in the content of lymphoid cells in the spleen. Meanwhile the newborn recipients of the tumor do not develop leukemoid response but manifest physiological changes in the hemopoietic tissue normally occurring within the first weeks after birth. The sensitized cells of the spleen of the adult tumor-bearing mice enhance tumor growth in the newborn recipients and inhibit it in the adult mice. Spleen cells of normal adult donors do not affect tumor growth in the newborn recipients. The data obtained suggest that the opposite effect of the transferred sensitized spleen cells from the adult animals on tumor growth in the newborn and adult mice is related to the age-associated features of the immune system of recipient mice.
ISSN:0365-9615