Effect of ethionamide and sodium succinate on NADPH-dependent oxidaton in the liver

A single administration of ethionamide (LD50) to guinea pigs causes an inhibition of p-hydroxylation and N-demethylation in the liver. Sodium succinate favours the activation and, when it is used for correction of the ethionamide toxic effect, it normalizes the above-mentioned processes.

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Bibliographic Details
Published inUkrainskij biohimičeskij žurnal Vol. 52; no. 5; p. 593
Main Author Korzhov, V I
Format Journal Article
LanguageRussian
Published Ukraine 01.09.1980
Subjects
Animals
Ethionamide - pharmacology
Guinea Pigs
Hydroxylation
Kinetics
Liver - drug effects
Liver - metabolism
NADP - metabolism
Oxidation-Reduction
Succinates - pharmacology
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Summary:A single administration of ethionamide (LD50) to guinea pigs causes an inhibition of p-hydroxylation and N-demethylation in the liver. Sodium succinate favours the activation and, when it is used for correction of the ethionamide toxic effect, it normalizes the above-mentioned processes.
ISSN:0201-8470