Exploration of the complement system in clinical practice

The complement system plays an important role in defence of the host against infection and in the clearance of immune complexes. Defects in complement proteins are often associated with infections or auto-immune/immune complex diseases. Investigation of complement is useful for diagnosis and followi...

Full description

Saved in:
Bibliographic Details
Published inArchives de pédiatrie : organe officiel de la Société française de pédiatrie Vol. 1; no. 1; p. 71
Main Authors Frémeaux-Bacchi, V, Blouin, J, Weiss, L
Format Journal Article
LanguageFrench
Published France 01.01.1994
Subjects
Child
Complement Activation
Complement System Proteins - deficiency
Complement System Proteins - metabolism
Glomerulonephritis - metabolism
Humans
Lupus Erythematosus, Systemic - metabolism
Online AccessGet more information

Cover

More Information
Summary:The complement system plays an important role in defence of the host against infection and in the clearance of immune complexes. Defects in complement proteins are often associated with infections or auto-immune/immune complex diseases. Investigation of complement is useful for diagnosis and following of autoimmune diseases. Hypocomplementemia may result from genetic deficiency and/or consumption through activation of the system. In the particular case of angioneurotic oedema, laboratory data are essential to confirm the diagnosis and to the follow-up of the patients. Inappropriate activation of the complement system associated with the release of inflammatory mediators contributes to the tissue damage.
ISSN:0929-693X