Local preventive antibacterial therapy with polymer biocompatible combination

• Published in: Meditsinskaia tekhnika no. 4; p. 37
• Main Authors: Volenko, A V, Belykh, S I, Firsova, E V, Kravchuk, Zh N
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.07.1994
• Subjects: Administration, Topical; Animals; Biocompatible Materials - pharmacology; Biocompatible Materials - therapeutic use; Follow-Up Studies; Humans; Polymers - pharmacology; Polymers - therapeutic use; Polymethacrylic Acids - therapeutic use; Povidone - analogs & derivatives; Povidone - therapeutic use; Rats; Rats, Wistar; Staphylococcal Infections - drug therapy; Staphylococcal Infections - physiopathology; Surgical Wound Infection - drug therapy; Surgical Wound Infection - physiopathology; Time Factors; Wound Healing - drug effects
• ISSN: 0025-8075

The paper provides data on the properties of the powdery antimicrobial absorbent Ambipor and the procedure of its use in the prevention of postoperative suppuration, which consists in application of the powder to the wound surface with a broken layer just before wound suture. It shows that a single application of Ambipor to wound suture. It shows that a single application of Ambipor to wound tissues at the end of an operation ensures high paravulnar tissue antibiotic concentrations which are many times higher those used in conventional antibacterial therapy. Implantation of Ambipor to operative wound tissue at the end of an operation aids to reduce the extent microbial dissemination by more than 100-1000 times, to accelerate reparative processes, stimulate early fibroplast activation, fibrillogenesis, scarring tissue maturation. Topical antibacterial therapy with the developed formulations is an effective tool in preventing postoperative wound complications. Its application to clinical practice enables the incidence of complications to be decreased by more than 4.5 times higher than those in the controls.