Intracranial distribution of iohexol and iotrolan after cervical myelography

Twenty-eight consecutive patients undergoing cervical myelography were examined with either iohexol (14) or iotrolan (14). Just before the myelography a cranial CT was performed and control CT (3-5 slices) examinations were performed three, six, 24 and 48 hours afterwards. In all 28 patients CT show...

Full description

Saved in:
Bibliographic Details
Published inUgeskrift for læger Vol. 157; no. 27; p. 3901
Main Authors Fiirgaard, B, Madsen, H H, Svare, U, Skjødt, T, Zeeberg, I
Format Journal Article
LanguageDanish
Published Denmark 03.07.1995
Subjects
Adult
Aged
Brain - diagnostic imaging
Brain - metabolism
Female
Humans
Iohexol - metabolism
Iohexol - pharmacokinetics
Male
Middle Aged
Myelography
Prospective Studies
Tomography, X-Ray Computed
Triiodobenzoic Acids - metabolism
Triiodobenzoic Acids - pharmacokinetics
Online AccessGet more information

Cover

More Information
Summary:Twenty-eight consecutive patients undergoing cervical myelography were examined with either iohexol (14) or iotrolan (14). Just before the myelography a cranial CT was performed and control CT (3-5 slices) examinations were performed three, six, 24 and 48 hours afterwards. In all 28 patients CT showed intracranial contrast medium distribution after cervical myelography. The contrast medium distributed mainly in the subarachnoid space, first to the basal cisterns and the insular fissures, and to the 4th ventricle. The densities in the subarachnoid spaces were significantly higher after iotrolan than iohexol in the basal cisterns three and six hours after myelography, and in the 4th ventricle. The subcortical density was still increasing 48 hours after iotrolanmyelography while the subcortical density reached the maximum 24 hours after iohexolmyelography. Following cervical myelography the contrast media iohexol and iotrolan distribute intracranially and iotrolan seems to be eliminated more slowly than iohexol.
ISSN:0041-5782