Use of tuftsin in experimental leprosy

The effect of tuftsin was studied in vivo using CBA mice infected with M. leprae by Shepard's technique and in vitro using macrophage-like cell line P. 388 (Co-cultivated with M. leprae) and the cultivated leproma tissue. It was found out that tuftsin acted as a stimulator of M. leprae multipli...

Full description

Saved in:
Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 112; no. 8; p. 181
Main Authors Vishnevetskiĭ, F E, Freĭdlin, I S, Iushchenko, A A, Vishnevetskiĭ, R F, Anokhina, V V, Urliapova, N G, Iushin, M Iu, Eskina, I M
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.08.1991
Subjects
Animals
Cell Line
Dapsone - therapeutic use
Leprosy - drug therapy
Mice
Mice, Inbred CBA
Mycobacterium leprae - growth & development
Rifampin - therapeutic use
Tuftsin - therapeutic use
Online AccessGet more information

Cover

More Information
Summary:The effect of tuftsin was studied in vivo using CBA mice infected with M. leprae by Shepard's technique and in vitro using macrophage-like cell line P. 388 (Co-cultivated with M. leprae) and the cultivated leproma tissue. It was found out that tuftsin acted as a stimulator of M. leprae multiplication in foot-pads of mice and as a prolongator of M. leprae survival in the cells of macrophage-like cell line P .388. It is concluded that using tuftsin might be useful in view of studying different aspects of experimental leprosy.
ISSN:0365-9615