Necrotizing histiocytic lymphadenitis (Kikuchi-Fujimoto disease): contribution of 2 cases

The necrotizing lymphadenitis of Kikuchi-Fujimoto is an uncommon disease in Spain. In a review of the literature we found only five cases reported until 1995. We report here two patients with the diagnosis of this entity in an area hospital during a one-year period. This fact contrasts with the low...

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Bibliographic Details
Published inRevista clínica espanõla Vol. 196; no. 10; p. 706
Main Authors Torres Martínez, M, Masiá Canuto, M, Gómez Tierno, A, Gutiérrez Rodero, F, Benito Santaleocadia, C, Vilar Zanón, A
Format Journal Article
LanguageSpanish
Published Spain 01.10.1996
Subjects
Adult
Female
Histiocytes - pathology
Humans
Lymphadenitis - epidemiology
Lymphadenitis - pathology
Necrosis
Spain - epidemiology
Spain
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Summary:The necrotizing lymphadenitis of Kikuchi-Fujimoto is an uncommon disease in Spain. In a review of the literature we found only five cases reported until 1995. We report here two patients with the diagnosis of this entity in an area hospital during a one-year period. This fact contrasts with the low frequency of this disease reported so far in our country. The cases were two young women who were investigated because of cervical lymph node enlargement and headache. The lymph node biopsy revealed typical findings of the necrotic phase of the Kikuchi-Fujimoto disease in one case; the histology in the other case was characteristic of the so called proliferative phase. The two patients evolved spontaneously with a favorable outcome. Lymph node enlargements resolved in less than three months. All microbiological investigations performed were negative. One of the two patients was receiving intranasal calcitonin when symptoms developed. The incidence of Kikuchi-Fujimoto disease might be higher than considered. The spontaneous resolution of the disease and the requirement of the histological examination for its diagnosis are factors limiting its identification.
ISSN:0014-2565