Uncoupling effect of dicarbonic analogs of stearic and palmitic acids in heart mitochondria

The uncoupling effect of 2-hexadecylmalonic acid (HDMA) and 2-tetradecylmalonic acid (TDMA), the dicarboxylic derivatives of stearic and palmitic acids, have been studied in heart mitochondria. The effects of these compounds and related fatty acids on the induced by ascorbate oxidation with PMS (or...

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Bibliographic Details
Published inBiokhimiia (Moscow, Russia) Vol. 59; no. 6; p. 911
Main Authors Bondarenko, D I, Dedukhova, V I, Mokhova, E N
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.06.1994
Subjects
Animals
Atractyloside - analogs & derivatives
Atractyloside - pharmacology
Mitochondria, Heart - drug effects
Mitochondria, Heart - metabolism
Oligomycins - pharmacology
Oxidation-Reduction
Palmitic Acids - pharmacology
Phosphates - pharmacology
Rats
Rotenone - pharmacology
Stearic Acids - pharmacology
Uncoupling Agents - pharmacology
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Summary:The uncoupling effect of 2-hexadecylmalonic acid (HDMA) and 2-tetradecylmalonic acid (TDMA), the dicarboxylic derivatives of stearic and palmitic acids, have been studied in heart mitochondria. The effects of these compounds and related fatty acids on the induced by ascorbate oxidation with PMS (or TMPD) in the presence of oligomycin, phosphate and rotenone have been compared. It was found that both HDMA and TDMA uncoupled mitochondria with a similar efficiency as did the corresponding fatty acids, while the uncoupling effect of low concentrations of HDMA and TDMA were almost completely suppressed by carboxyatractylate.
ISSN:0320-9725