Multifactor analysis of parameters of immunity under the combined action of doxycycline and a low molecular weight immunomodulator of microbial origin

The effect of doxycycline combination with a low molecular immunomodulator of microbial origin on the primary immune response to the vaccine EV antigens was studied in multifactor experiments. Mathematical processing of the data provided construction of polynomial statistic models of the second orde...

Full description

Saved in:
Bibliographic Details
Published inAntibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] Vol. 34; no. 7; p. 526
Main Authors Nikitin, A V, Fomina, I P, Ivanitskaia, L P, Fishman, V M, Bodunkova, L E
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.1989
Subjects
Adjuvants, Immunologic - administration & dosage
Adjuvants, Immunologic - therapeutic use
Animals
Antigens - immunology
Doxycycline - administration & dosage
Doxycycline - therapeutic use
Drug Therapy, Combination
Factor Analysis, Statistical
Hypersensitivity, Delayed
Immunity - drug effects
Male
Mice
Mice, Inbred CBA
Molecular Weight
Online AccessGet more information

Cover

More Information
Summary:The effect of doxycycline combination with a low molecular immunomodulator of microbial origin on the primary immune response to the vaccine EV antigens was studied in multifactor experiments. Mathematical processing of the data provided construction of polynomial statistic models of the second order describing increased delayed type hypersensitivity (IDTH) and the antibody titer. Analysis of the quasimonofactor models revealed different character of regulation of the cellular and humoral response. Nomograms were plotted for precise quantitative estimation of the dose-time parameters of the regimens for combined use of the antibiotic and immunomodulator providing the required levels of IDTH and the antibody titer.
ISSN:0235-2990