Structuro-functional characteristics of the human coronary arteries in atherosclerosis

Structural features of the endothelium interaction with the blood cellular elements during atherosclerotic processes of varying severity in the coronary arteries have been analyzed from the data of early sections and coronary artery biopsy specimens. The status of the endothelium has been uniform in...

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Bibliographic Details
Published inArkhiv patologii Vol. 51; no. 2; p. 15
Main Authors Nagornev, V A, Zhuravleva, T B, Bobryshev, Iu V
Format Journal Article
LanguageRussian
Published Russia (Federation) 1989
Subjects
Adult
Aged
Arteriosclerosis - pathology
Cell Adhesion
Coronary Vessels - pathology
Coronary Vessels - ultrastructure
Endothelium, Vascular - pathology
Endothelium, Vascular - ultrastructure
Female
Humans
Lipoproteins, LDL - analysis
Male
Microscopy, Electron, Scanning
Middle Aged
Monocytes - pathology
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Summary:Structural features of the endothelium interaction with the blood cellular elements during atherosclerotic processes of varying severity in the coronary arteries have been analyzed from the data of early sections and coronary artery biopsy specimens. The status of the endothelium has been uniform in macroscopically unchanged sites irrespective of the coronary atherosclerosis severity. A stable characteristic symptom of the initial stages of atherogenesis is the formation of crater-like defects and monocyte adhesion. Scanning electron microscopy has shown for the first time the presence of echinocytes in the blood of coronary patients and adhesion of these cells at the site of the endothelial monolayer destruction. The formation of microthrombi at the site of endothelial destruction is not a stable symptom of the initial stages of atherogenesis. Endothelial destruction and regeneration, aided by the platelets, can be observed at all stages of atherogenesis.
ISSN:0004-1955