Cytoplasmatic androgen receptors in malignant bone neoplasms and their relation to the morphological characteristics of the tumor

• Published in: Arkhiv patologii Vol. 49; no. 5; p. 52
• Main Authors: Kushlinskiĭ, N E, Siniukov, P A, Petrovichev, N N, Vasil'ev, A V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 1987
• Subjects: Adolescent; Adult; Bone Neoplasms - analysis; Bone Neoplasms - pathology; Chondrosarcoma - analysis; Chondrosarcoma - pathology; Cytoplasm - analysis; Female; Humans; Male; Middle Aged; Neoplasms, Hormone-Dependent - analysis; Neoplasms, Hormone-Dependent - pathology; Osteosarcoma - analysis; Osteosarcoma - pathology; Radioligand Assay; Receptors, Androgen - analysis; Testosterone - blood
• ISSN: 0004-1955

"Free" and "total" (the sum of the occupied and free sites of binding) androgen receptors (AR) in the cytosolic fraction of 51 bone tumors were studied with reference to their histologic structure and treatment. "Free" AR were found in chondrosarcomas and osteogenic sarcomas previously treated two times more frequently than in untreated tumors. It is found that in untreated osteogenic sarcomas much more "total" AR in the cytoplasm are occupied with an endogenic androgen than in the treated tumors. More than a half of "total" AR in the cytoplasm of chondrosarcomas are bound with an endogenic androgen. The authors believe chondrosarcomas and osteogenic sarcomas treated with radiation and adriamycin to be more susceptible to the androgens than untreated osteogenic sarcomas. The evaluation of the susceptibility to the androgens of bone tumors which are followed or possibly stipulated by the metabolic disturbances of sex steroid hormones will be of value in the study of bone tumor hormonal regulation.