Proteolytic mechanisms in bronchial secretions in rats with bronchial anaphylaxis

Serine elastase-like proteinase was isolated from rat bronchial secretion, activity of which was increased 2-fold in bronchial anaphylaxis. Effect of histamine, serotonin and hydrocortisone on the enzymatic activity was studied. Regulation of the enzyme activity in bronchial anaphylaxis was consider...

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Bibliographic Details
Published inVoprosy meditsinskoi khimii Vol. 38; no. 1; p. 18
Main Authors Komov, V P, Spasenkova, O M, Strelkova, M A
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.1992
Subjects
Anaphylaxis - metabolism
Animals
Bronchi - enzymology
Bronchi - secretion
Enzyme Activation
Histamine - physiology
Hydrocortisone - physiology
Hydrogen-Ion Concentration
Hydrolysis
Male
Rats
Serine Endopeptidases - metabolism
Serotonin - physiology
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Summary:Serine elastase-like proteinase was isolated from rat bronchial secretion, activity of which was increased 2-fold in bronchial anaphylaxis. Effect of histamine, serotonin and hydrocortisone on the enzymatic activity was studied. Regulation of the enzyme activity in bronchial anaphylaxis was considered with relation to patterns of its metabolism as well as depending on efficiency of specific endogenous inhibitor of the proteinase. A procedure for histamine stimulation of alkaline proteinase was developed.
ISSN:0042-8809