Cystinosis, hyperparathyroidism and metastatic calcifications (author's transl)

An 11-year-old boy died from uraemia in the course of cystinosis. In addition to the renal lesions common to this disease he had also developed nodular hyperplasia of the parathyroids and widespread extra-osseous calcifications in lungs, kidneys, stomach, the muscular arteries, skin and subcutaneous...

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Bibliographic Details
Published inDeutsche medizinische Wochenschrift Vol. 101; no. 14; p. 545
Main Author Kunze, W P
Format Journal Article
LanguageGerman
Published Germany 01.04.1976
Subjects
Arteries
Autopsy
Calcinosis - complications
Calcinosis - pathology
Calciphylaxis - complications
Child
Cystinosis - complications
Cystinosis - pathology
Humans
Hyperparathyroidism - complications
Hyperparathyroidism - pathology
Kidney Diseases - complications
Lung Diseases - complications
Male
Skin Diseases - complications
Stomach Diseases - complications
Uremia - complications
Vascular Diseases - complications
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Summary:An 11-year-old boy died from uraemia in the course of cystinosis. In addition to the renal lesions common to this disease he had also developed nodular hyperplasia of the parathyroids and widespread extra-osseous calcifications in lungs, kidneys, stomach, the muscular arteries, skin and subcutaneous tissue. The calcifications and other features suggest that the hyperparathyroidism was a "tertiary" one, although this term is not generally accepted. The unusual cutaneous calcifications were probably due to calciphylaxis. As in this case, hyperparathyroidism and calcinosis can develop into a "second disease" which, due to the cystinosis, may follow a remarkably autonomous course.
ISSN:0012-0472