Effect of the new anti-arrhythmia preparation Bonnecor on the hemodynamics and activity of the ischemic heart

The effect of newly-developed anti-arrhythmia drug Bonnecor compared to that of ethacizin and lidocaine has been studied on anesthetized rats under acute myocardial ischemia. The drugs injected intravenously prior to coronary artery occlusion have been shown to prevent to a great degree the appearan...

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Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 107; no. 5; p. 588
Main Authors Tolmacheva, E A, Chichkanov, G G, Matsievskiĭ, D D
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1989
Subjects
Animals
Anti-Arrhythmia Agents - therapeutic use
Coronary Disease - drug therapy
Coronary Disease - physiopathology
Dibenzazepines - therapeutic use
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Hemodynamics - drug effects
Lidocaine - therapeutic use
Male
Myocardial Contraction - drug effects
Phenothiazines - therapeutic use
Rats
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Summary:The effect of newly-developed anti-arrhythmia drug Bonnecor compared to that of ethacizin and lidocaine has been studied on anesthetized rats under acute myocardial ischemia. The drugs injected intravenously prior to coronary artery occlusion have been shown to prevent to a great degree the appearance of hemodynamic and functional disturbances of the heart. When compared to control, less reduction in systemic arterial pressure, systolic discharge cardiac output, contractility and heart power were observed. In addition, Bonnecor has been found to have certain advantages over reference drugs.
ISSN:0365-9615