Effect of cytoskeleton-disrupting on the redistribution of the surface receptors of cultured cells

The capacity of cap-formation in cultured cells was shown to increase from 2 to 20 fold upon treating them with ligands in the presence of a conditioned medium. This permitted us to compare the influence of cytoskeleton-disrupting agents on the process of cap-formation in cultured cells of different...

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Bibliographic Details
Published inT͡S︡itologii͡a Vol. 25; no. 10; p. 1137
Main Authors Khomenko, A V, Pinaev, G P
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.10.1983
Subjects
Animals
Cell Line
Cells, Cultured
Colchicine - pharmacology
Concanavalin A - pharmacology
Cytochalasins - pharmacology
Cytoskeleton - drug effects
Demecolcine - pharmacology
Fibroblasts - drug effects
Fibroblasts - immunology
Immune Sera - pharmacology
Immunologic Capping - drug effects
Ligands
Lymphocytes - drug effects
Lymphocytes - immunology
Mice
Mice, Inbred BALB C
Vinblastine - pharmacology
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Summary:The capacity of cap-formation in cultured cells was shown to increase from 2 to 20 fold upon treating them with ligands in the presence of a conditioned medium. This permitted us to compare the influence of cytoskeleton-disrupting agents on the process of cap-formation in cultured cells of different origin. Cytochalasin was shown to inhibit cap-formation, induced with concanavalin A or anti-H2-serum, both in cells of lymphoid and fibroblastic origin. In contrast, vinblastin did not inhibit cap-formation in cells of lymphoid origin, but caused inhibition in cells of fibroblastic origin twice as strong as did cytochalasin B.
ISSN:0041-3771