The gamma-aminobutyric acid content of the blood plasma in patients with Itsenko-Cushing disease and its dependence on clinical and hormonal indices

• Published in: Terapevtic̆eskii arhiv Vol. 63; no. 10; p. 63
• Main Authors: Mishunina, T M, Kononenko, V Ia, Komissarenko, I V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 1991
• Subjects: 11-Hydroxycorticosteroids - urine; 17-Hydroxycorticosteroids - urine; 17-Ketosteroids - urine; Adrenalectomy; Adrenocorticotropic Hormone - blood; Adult; Chromatography, Ion Exchange; Chronic Disease; Combined Modality Therapy; Cushing Syndrome - blood; Cushing Syndrome - therapy; Cushing Syndrome - urine; Female; gamma-Aminobutyric Acid - blood; Humans; Hydrocortisone - blood; Male; Middle Aged
• ISSN: 0040-3660

The content of GABA was measured in blood plasma of 111 patients suffering from Itsenko-Cushing disease. In untreated females, the blood GABA content was noticeably lowered; during treatment it increased, reaching normal, on the average, in patients with a history of total adrenalectomy. The changes in the blood GABA content in male patients were marked to a less degree. In the persons with a history of total adrenalectomy the GABA content turned out higher than normal. The blood GABA content in patients was dependent on the age and disease standing. In males experiencing disease exacerbation, it was appreciably reduced. As compared to females, the degree of a negative correlation between the blood content of GABA and ACTH (or cortisol) in males was more pronounced. The correlation between the excretion of 17-HCS with urine and GABA blood content in men and women was reverse. Women manifested a positive correlation between the excretion of 17-HCS with urine and blood GABA content, whereas men between arterial pressure and blood GABA. The problem of potential disorders of the GABAergic brain system in patients afflicted with Itsenko-Cushing disease is under discussion.