Granisetron versus granisetron plus methylprednisolone in the prevention of chemotherapy induced nausea and vomiting--in adjuvant chemotherapy, including CDDP against gastric cancer

• Published in: Gan to kagaku ryoho Vol. 24; no. 1; p. 49
• Main Authors: Kurita, A, Takashima, S, Nakata, M, Kubo, Y, Saiki, T, Ohsumi, S, Yokoyama, N, Tanada, M, Takiyama, W, Saeki, H
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.01.1997
• Subjects: Antiemetics - administration & dosage; Chemotherapy, Adjuvant; Cisplatin - adverse effects; Female; Gastrectomy; Granisetron - administration & dosage; Humans; Male; Methylprednisolone - administration & dosage; Middle Aged; Nausea - chemically induced; Nausea - prevention & control; Stomach Neoplasms - drug therapy; Stomach Neoplasms - surgery; Vomiting - chemically induced; Vomiting - prevention & control
• ISSN: 0385-0684

CDDP is one of the most effective drugs in chemotherapy for gastric cancer. We compared the antiemetic effect of a combination of granisetron and methylprednisolone with that of granisetron administered alone. Twenty postgastrectomy-patients who were to receive moderately emetogenic chemotherapy, including CDDP, were enrolled in randomized fashion to evaluate the efficacy and toxicity of two antiemetic regimens. The following antiemetic regimens were used: 3 mg of granisetron given intravenously before chemotherapy (11 patients) or a combination of granisetron and 250 mg of methylprednisolone in the same manner (9 patients). Granisetron combined with methylprednisolone tender to be more effective than granisetron alone. The adverse effects were very mild. Their efficacy against delayed emesis is still not entirely satisfactory.