Effect of large heparin doses on the contractile function, structure and lipid metabolic indices of the myocardium in intact rabbits

The effect of large doses (700 U/kg daily for 6 days) of heparin on the heart contractile function, myocardial morphology, content of free fatty acids in the blood, and the activity of tri- and monoglycerin lipase in blood plasma and heart tissue of intact rabbits was studied 24, 72 hours and 6 days...

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Published inKardiologiia Vol. 20; no. 7; p. 92
Main Authors Frolov, V A, Demurov, E A, Efimova, L V, Kazanskaia, T A, Pukhlianko, V P
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.1980
Subjects
Animals
Electrocardiography
Enzyme Activation - drug effects
Fatty Acids, Nonesterified - metabolism
Heart - drug effects
Heparin - administration & dosage
Lipid Metabolism
Male
Myocardial Contraction - drug effects
Myocardium - metabolism
Rabbits
Time Factors
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Summary:The effect of large doses (700 U/kg daily for 6 days) of heparin on the heart contractile function, myocardial morphology, content of free fatty acids in the blood, and the activity of tri- and monoglycerin lipase in blood plasma and heart tissue of intact rabbits was studied 24, 72 hours and 6 days after the beginning of heparin administration. It was established that the activity of lipolytic enzymes intensified, the concentration of free fatty acids in blood plasma grows, and the myocardial contractility increases after heparin administration. The phase structure of the cardiac cycle is simultaneously disturbed slightly. It is concluded that the intensification of lipolysis plays a role in increasing the myocardial contractility.
ISSN:0022-9040