Immunity to tumors induced by herpes simplex virus in hamsters

Preparations of early herpes simplex virus antigen (VIA) and specific antibodies to it were used to induce active and passive immunity to herpes virus-induced tumors in experimental animals. The results demonstrated the increased resistance of animals to transplantation of tumor cells due to vaccina...

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Bibliographic Details
Published inVoprosy virusologiĭ Vol. 36; no. 1; p. 40
Main Authors Kosiakov, P N, Posevaia, T A, Kosiakova, N P, Barinskiĭ, I F
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.1991
Subjects
Animals
Antibodies, Viral - blood
Antibodies, Viral - immunology
Antibody Specificity - immunology
Antigens, Viral - immunology
Cricetinae
Herpes Simplex - etiology
Herpes Simplex - immunology
Herpes Simplex - mortality
Immunization, Passive
Immunoglobulin G - administration & dosage
Immunoglobulin G - analysis
Mesocricetus
Neoplasm Transplantation
Neoplasms, Experimental - etiology
Neoplasms, Experimental - immunology
Simplexvirus - immunology
Simplexvirus - pathogenicity
Time Factors
Vaccination
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Summary:Preparations of early herpes simplex virus antigen (VIA) and specific antibodies to it were used to induce active and passive immunity to herpes virus-induced tumors in experimental animals. The results demonstrated the increased resistance of animals to transplantation of tumor cells due to vaccination with VIA-containing preparations. Thus, in VIA-vaccinated animals there was a delay in the development of tumors and the survival time was significantly higher than in the controls. The sera of these animals contained antibodies to VIA in high titres. Experiments with passive immunization also gave encouraging results.
ISSN:0507-4088