Changes in the intermediate filament cytoskeleton of liver cells in alcoholic liver injury

Mallory bodies are a morphological key feature of severe alcoholic liver cell injury (alcoholic hepatitis) and the morphological expression of dysregulation and derangement of the intermediate filament cytoskeleton of the hepatocyte. Their pathogenesis is still unclear. Studies on Mallory body forma...

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Bibliographic Details
Published inWiener Klinische Wochenschrift Vol. 97; no. 8; p. 354
Main Authors Denk, H, Lackinger, E
Format Journal Article
LanguageGerman
Published Austria 12.04.1985
Subjects
Animals
Chemical and Drug Induced Liver Injury - etiology
Colchicine - physiology
Cytoskeleton - analysis
Cytoskeleton - ultrastructure
Electrophoresis, Polyacrylamide Gel
Endoplasmic Reticulum - ultrastructure
Fluorescent Antibody Technique
Griseofulvin - toxicity
Hepatitis, Alcoholic - pathology
Humans
Isoantibodies - analysis
Isoelectric Focusing
Keratins - analysis
Keratins - immunology
Liver - ultrastructure
Liver Cirrhosis, Alcoholic - pathology
Mice
Microscopy, Electron
Rats
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Summary:Mallory bodies are a morphological key feature of severe alcoholic liver cell injury (alcoholic hepatitis) and the morphological expression of dysregulation and derangement of the intermediate filament cytoskeleton of the hepatocyte. Their pathogenesis is still unclear. Studies on Mallory body formation may not only help to elucidate the mechanisms of liver cell injury associated with alcoholic hepatitis, but may also contribute to our understanding of the regulation and function of the intermediate filament cytoskeleton.
ISSN:0043-5325