Survival analysis in cirrhotic patients

• Published in: Revista de gastroenterología de México Vol. 61; no. 3; pp. 226 - 232
• Main Authors: Rodríguez-Hernández, H, Guerrero-Romero, J F, Jacobo-Karam, J S, Rodríguez-Morán, M
• Format: Journal Article
• Language: Spanish
• Published: Mexico 01.07.1996
• Subjects: Adult; Aged; Female; Follow-Up Studies; Humans; Liver Cirrhosis - complications; Liver Cirrhosis - mortality; Male; Middle Aged; Survival Analysis
• ISSN: 0375-0906

Hepatic cirrhosis (HC) is a chronic and progressive disease that, independently of its etiology, favors the presence of some complications that impair the survival of patients. To determine the frequency, etiology, and main decompensation factors, as well as analyse survival curves in HC of a population of Durango, México. Cirrhotic patients of both sexes from the Hospital General del IMSS in Durango were included. The etiology of cirrhosis, the factors of decompensation and the grade of portal hypertension (PHT) were determined. A 39 month follow-up was done, registering complications and cause of death. Fisher's exact test, Friedman's variance analysis, Mantel-Haenzsel chi-square test and Kaplan-Meier methods were used. Fifty patients were studied, 30 female and 20 male. The mean age was 54.3 years old (range 32-74 years). The more frequent etiology was alcoholic in 42% patients (19 male and 2 female). Forty three patients (86%) had decompensation by ascitis; 19 (38%) had variceal bleeding, 18(36%) had encephalopathy and 16(32%) were icteric. Twenty six patients (52%) had PHT III, and 30 (60%) were Child-Pugh class B. Survival in the decompensated group at 19.8 months follow-up was 62% and 73% in the total group, 20% died. Statistical significance (p < 0.05) was found between PHT grade and Child-Pugh functional class; hepatic reserve correlated inversely with bleeding (p < 0.05) and encephalopathy (p < 0.05) probability. The advanced grade of PHT directly correlated with bleeding encephalopathy and mortality (p < 0.05). We did not find any association between the etiology of cirrhosis and the incidence of complications.