Structural and functional characteristics of endothelial surface of the aorta in experimental hypercholesterolemia

Structural and functional characteristics of the surface of aortal endothelium in experimental hypercholesterolemia in rabbits are presented. Scanning and transmissive electron microscopy showed deendothelization of the aorta to be a secondary factor due to activation of nonspecific endocytosis of l...

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Bibliographic Details
Published inArkhiv patologii Vol. 46; no. 1; p. 50
Main Authors Nagornev, V A, Bobryshev, Iu V
Format Journal Article
LanguageRussian
Published Russia (Federation) 1984
Subjects
Animals
Aorta, Thoracic - ultrastructure
Cell Membrane - metabolism
Endocytosis
Endothelium - ultrastructure
Hypercholesterolemia - pathology
Lipoproteins, LDL - metabolism
Microscopy, Electron
Microscopy, Electron, Scanning
Rabbits
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Summary:Structural and functional characteristics of the surface of aortal endothelium in experimental hypercholesterolemia in rabbits are presented. Scanning and transmissive electron microscopy showed deendothelization of the aorta to be a secondary factor due to activation of nonspecific endocytosis of lipoproteins. Microatheromas with parietal adhesion of thrombocytes and monocytes were found to form in the very early stages of formation of experimental atherosclerotic changes in the rabbit aorta.
ISSN:0004-1955