Effect of verapamil on arterial pressure and various parameters of heart contractile function in rabbits with prerenal artery hypertension when administered at various times of day

The dynamics of arterial blood pressure and some data of cardiac contractility in rabbits with vasorenal hypertension were investigated in 4 seasons of the year. Simultaneously, the effects of verapamil on the said data were studied in rabbits with vasorenal hypertension (verapamil was administered...

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Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 115; no. 1; p. 41
Main Authors Lepakhin, V K, Frolov, V A, Matyev, E S, Kazanskaia, T A, Mogilevskiĭ, V A
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.1993
Subjects
Animals
Blood Pressure - drug effects
Circadian Rhythm - drug effects
Drug Administration Schedule
Hypertension, Renovascular - drug therapy
Hypertension, Renovascular - physiopathology
Male
Myocardial Contraction - drug effects
Rabbits
Seasons
Verapamil - pharmacology
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Summary:The dynamics of arterial blood pressure and some data of cardiac contractility in rabbits with vasorenal hypertension were investigated in 4 seasons of the year. Simultaneously, the effects of verapamil on the said data were studied in rabbits with vasorenal hypertension (verapamil was administered at 12 and 18 h during last 2 weeks of experiment). In different seasons the definite differences in therapeutic effect of verapamil depending on the time of its administration were revealed.
ISSN:0365-9615