The effect of modification of excipients for the bioavailability of vinburnine

Biopharmaceutic comparison is achieved between commercialized capsules of vinburnine and a new dosage form. The difference between the two drug products concerns only the quality of excipients. Drug bioavailability decreases of about 10%, in despite of the very important, and well known, interindivi...

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Bibliographic Details
Published inJournal de pharmacie de Belgique Vol. 44; no. 3; p. 221
Main Authors Sado, P A, Gibassier, D, Leverge, R
Format Journal Article
LanguageFrench
Published Belgium 01.05.1989
Subjects
Adult
Biological Availability
Excipients
Female
Humans
Male
Vinca Alkaloids - pharmacokinetics
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Summary:Biopharmaceutic comparison is achieved between commercialized capsules of vinburnine and a new dosage form. The difference between the two drug products concerns only the quality of excipients. Drug bioavailability decreases of about 10%, in despite of the very important, and well known, interindividual variations of vincamine drug products. Only the absorption rate seems statistically lightly decreased by the new formulation.
ISSN:0047-2166