Effect of bleomycetin on the proliferative activity of bone marrow and lymph node cells in SJL/J mice

Dynamics of dose and time dependence of bleomycin action on bone marrow and lymph node cells of SJL/J mice has shown that 6 h after administration of 25 micrograms of bleomycin the proliferative activity is 1.5 times reduced. The antibiotic influences the interphase cells and delays a cellular cycle...

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Published inEksperimentalʹnaja onkologija Vol. 6; no. 4; p. 73
Main Authors Markochev, A B, Neĭshtadt, E L, Gubareva, A V
Format Journal Article
LanguageRussian
Published Ukraine 1984
Subjects
Animals
Bleomycin - pharmacology
Bleomycin - therapeutic use
Mice
Mice, Inbred Strains
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Summary:Dynamics of dose and time dependence of bleomycin action on bone marrow and lymph node cells of SJL/J mice has shown that 6 h after administration of 25 micrograms of bleomycin the proliferative activity is 1.5 times reduced. The antibiotic influences the interphase cells and delays a cellular cycle. A durable and persistent decrease of the proliferative activity (up to 10 days) of bone marrow and lymph node cells shows a prolonged action of the bleomycin single dose and a pronounced cytostatic effect of the antibiotic on cellular elements of SJL/J mice. Bleomycetin is established to produce action both on lymph node and bone marrow tumour cells of SJL/J mice.
ISSN:0204-3564