Effect of bleomycetin on the proliferative activity of bone marrow and lymph node cells in SJL/J mice
Dynamics of dose and time dependence of bleomycin action on bone marrow and lymph node cells of SJL/J mice has shown that 6 h after administration of 25 micrograms of bleomycin the proliferative activity is 1.5 times reduced. The antibiotic influences the interphase cells and delays a cellular cycle...
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Published in | Eksperimentalʹnaja onkologija Vol. 6; no. 4; p. 73 |
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Main Authors | , , |
Format | Journal Article |
Language | Russian |
Published |
Ukraine
1984
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Subjects | |
Online Access | Get more information |
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Summary: | Dynamics of dose and time dependence of bleomycin action on bone marrow and lymph node cells of SJL/J mice has shown that 6 h after administration of 25 micrograms of bleomycin the proliferative activity is 1.5 times reduced. The antibiotic influences the interphase cells and delays a cellular cycle. A durable and persistent decrease of the proliferative activity (up to 10 days) of bone marrow and lymph node cells shows a prolonged action of the bleomycin single dose and a pronounced cytostatic effect of the antibiotic on cellular elements of SJL/J mice. Bleomycetin is established to produce action both on lymph node and bone marrow tumour cells of SJL/J mice. |
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ISSN: | 0204-3564 |