Effect of magnolia vine lignans on cell division processes in the corneal and lingual epithelium of white rats subjected to long-term exposure to cold stress

A study was made of the possibility of correcting with shizandra lignans of the cell manifestations of disadaptation in animals exposed to chronic cold stress. The stress was simulated by a 1.5-hour cooling of the animals to 28-30 degrees C for 28 days. The cell disadaptation test was used for deter...

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Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 98; no. 12; p. 718
Main Authors Mel'nik, E I, Timoshin, S S, Lupandin, A V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.12.1984
Subjects
Adaptation, Physiological - drug effects
Animals
Cell Division - drug effects
Cold Temperature - adverse effects
Cornea - drug effects
Drug Evaluation, Preclinical
Epithelium - drug effects
Lignans
Male
Plant Extracts - therapeutic use
Rats
Stress, Physiological - drug therapy
Stress, Physiological - physiopathology
Time Factors
Tongue - drug effects
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Summary:A study was made of the possibility of correcting with shizandra lignans of the cell manifestations of disadaptation in animals exposed to chronic cold stress. The stress was simulated by a 1.5-hour cooling of the animals to 28-30 degrees C for 28 days. The cell disadaptation test was used for determination of the level of pathological mitoses (PM). The processes of cell division were evaluated with the aid of the mitotic index and radioautography of DNA synthesis. Administration of shizandra to the stress-exposed animals for 28 days averted the stress-induced elevation of the PM level in the corneal epithelium. The use of shizandra lignans also promoted the normalization of DNA synthesis and mitotic activity in the tissues under examination.
ISSN:0365-9615