Are peroral antidiabetic agents neurotoxic?

The author discusses in conjunction with contemporary views on the genesis and development of diabetic neuropathy the view on the neurotoxicity of oral antidiabetics, in particular sulphonyl urea derivatives. He analyzes in more detail different areas of pathogenesis of diabetics neuropathy, the mai...

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Bibliographic Details
Published inČasopis lékařů českých Vol. 129; no. 51; p. 1601
Main Author Kalita, Z
Format Journal Article
LanguageCzech
Published Czech Republic 21.12.1990
Subjects
Administration, Oral
Diabetic Neuropathies - chemically induced
Humans
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - adverse effects
Hypoglycemic Agents - pharmacology
Nervous System - drug effects
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Summary:The author discusses in conjunction with contemporary views on the genesis and development of diabetic neuropathy the view on the neurotoxicity of oral antidiabetics, in particular sulphonyl urea derivatives. He analyzes in more detail different areas of pathogenesis of diabetics neuropathy, the main one being the metabolic and hypoxic one with the common trigger mechanism--hyperglycaemia. Therefore, based on contemporary knowledge, the neurotoxicity of oral antidiabetics can be ruled out.
ISSN:0008-7335