Immune disorders and sensitization to microbial antigens in seronegative spondylitis

• Published in: Terapevtic̆eskii arhiv Vol. 63; no. 5; p. 69
• Main Authors: Davtian, V G, Garib, F Iu, Belen'kiĭ, A G, Saliev, T S
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 1991
• Subjects: Antigens, Bacterial - immunology; Arthritis, Infectious - immunology; Arthritis, Psoriatic - immunology; Arthritis, Reactive - immunology; B-Lymphocytes - immunology; HLA-B27 Antigen - immunology; Humans; Immune System Diseases - immunology; Immunization; Klebsiella pneumoniae - immunology; Leukocyte Count; Spondylitis, Ankylosing - immunology; T-Lymphocytes - immunology; Yersinia enterocolitica - immunology
• ISSN: 0040-3660

A study was made of immunity in seronegative spondylarthritis. In ankylosing spondylarthritis, reactive arthritides and psoriatic arthritis, the decrease of T cells, T helpers and T suppressors was identified. Patients with ankylosing spondylarthritis and reactive arthritides manifested an increase of the B-lymphocyte count. Patients with ankylosing spondylarthritis were demonstrated to be sensitive to Klebsiella (52%), those with reactive arthritides to intestinal yersinia (44%). The phenotype of antigen-binding cells was examined. Of these, 39% appeared to be T lymphocytes, 29% B lymphocytes. The presence of Fc receptors in an appreciable portion of those cells suggests their functional maturity. The inhibition test demonstrated the participation of HLA-B27 in reception of Klebsiella antigens in ankylosing spondylarthritis.