A pharmacokinetic study of korinfar-retard in monotherapy and in combination with cordanum and triampur in patients with arterial hypertension

The long-acting corinfar formulation, corinfar-retard tablets, 20 mg (AWD, Germany), was studied for pharmacokinetics in single and course use in 40 patients with arterial hypertension, as well as for its effects of cordanum and triampur. Patients' plasma corinfar was measured by high performan...

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Published inĖksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 57; no. 6; p. 50
Main Authors Kukes, V G, Ignat'ev, V I, Kurapov, A P, Pavlov, S S, Rumiantsev, A S, Chil'tsov, V V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1994
Subjects
Adolescent
Adrenergic beta-Antagonists - blood
Adrenergic beta-Antagonists - pharmacokinetics
Adrenergic beta-Antagonists - therapeutic use
Adult
Aged
Antihypertensive Agents - blood
Antihypertensive Agents - pharmacokinetics
Antihypertensive Agents - therapeutic use
Chromatography, Liquid
Delayed-Action Preparations
Drug Combinations
Drug Therapy, Combination
Humans
Hydrochlorothiazide - blood
Hydrochlorothiazide - pharmacokinetics
Hydrochlorothiazide - therapeutic use
Hypertension - blood
Hypertension - drug therapy
Middle Aged
Nifedipine - blood
Nifedipine - pharmacokinetics
Nifedipine - therapeutic use
Propanolamines - blood
Propanolamines - pharmacokinetics
Propanolamines - therapeutic use
Spectrophotometry, Ultraviolet
Tablets
Time Factors
Triamterene - blood
Triamterene - pharmacokinetics
Triamterene - therapeutic use
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Summary:The long-acting corinfar formulation, corinfar-retard tablets, 20 mg (AWD, Germany), was studied for pharmacokinetics in single and course use in 40 patients with arterial hypertension, as well as for its effects of cordanum and triampur. Patients' plasma corinfar was measured by high performance liquid chromatography. There were no changes in the pharmacokinetics of the agent when it was used in its course use. Cordanum and triampur was demonstrated to have no effects on the pharmacokinetics of corinfar during their application.
ISSN:0869-2092