Effect of anti-inflammatory preparations on the osteoinductive activity of bone tissue

The effects of steroid (dexamethasone) and nonsteroid (indomethacin) anti-inflammatory drugs on the composition and the osteoinductive activity of bone tissue were studied on rats. Dexamethasone was found to induce bone tissue demineralisation and dose-dependent suppression of the osteoinductive act...

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Bibliographic Details
Published inFarmakologiia i toksikologiia Vol. 51; no. 6; p. 73
Main Authors Sumarokov, D D, Gutkin, D V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1988
Subjects
Animals
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Bone and Bones - drug effects
Bone Regeneration - drug effects
Bone Transplantation
Decalcification Technique
Dexamethasone - pharmacology
Dose-Response Relationship, Drug
Indomethacin - pharmacology
Male
Osteogenesis - drug effects
Rats
Time Factors
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Summary:The effects of steroid (dexamethasone) and nonsteroid (indomethacin) anti-inflammatory drugs on the composition and the osteoinductive activity of bone tissue were studied on rats. Dexamethasone was found to induce bone tissue demineralisation and dose-dependent suppression of the osteoinductive activity, i.e. the ability to cause ectopic osteogenesis. Indomethacin, on the contrary, increases the osteoinductive activity of bone tissue. The findings are suggested to be due to different effect of steroid and nonsteroid anti-inflammatory drugs on the synthesis of prostaglandins and leukotrienes.
ISSN:0014-8318