Status of liver mitochondria and rat tissue creatine kinase during administration of antivitamin K

It has been shown that 16-18 days administration of antivitamin K (pelentan) leads to two-fold increase of prothrombin time in adult rats but does not influence the soluble brain, renal, heart, muscle and serum creatine kinase activity. No effect on metabolic function of isolated liver mitochondria...

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Published inUkrainskij biohimičeskij žurnal Vol. 63; no. 5; p. 102
Main Authors Sokol'nikov, A A, Zharova, T V, Tiulina, O V, Kodentsova, V M, Leĭkin, Iu N
Format Journal Article
LanguageRussian
Published Ukraine 01.09.1991
Subjects
Animals
Brain - drug effects
Brain - enzymology
Creatine Kinase - drug effects
Ethyl Biscoumacetate - pharmacology
Heart - drug effects
Kidney - drug effects
Kidney - enzymology
Male
Mitochondria, Liver - drug effects
Muscles - drug effects
Muscles - enzymology
Myocardium - enzymology
Oxygen Consumption - drug effects
Prothrombin Time
Rats
Rats, Inbred Strains
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Summary:It has been shown that 16-18 days administration of antivitamin K (pelentan) leads to two-fold increase of prothrombin time in adult rats but does not influence the soluble brain, renal, heart, muscle and serum creatine kinase activity. No effect on metabolic function of isolated liver mitochondria has been found in contrast to the vitamin K deficient rats. Mitochondria were characterized by high value of respiration control; substance oxidation rates and internal mitochondrial Ca2+ content do not differ in the level from those of control animals. From the obtained results and data published in literature a conclusion can be drawn about only particular similarity (prothrombin time) between the antivitamin K administration and alimentary vitamin K deficit.
ISSN:0201-8470