The effect of cyclooxygenase inhibition on the indices of the thrombocyte-vascular link in hemostasis and on the free-radical processes of lipid oxidation in experimental Salmonella intoxication

Injection of Salmonella typhimurium endotoxin to the laboratory animals (rabbits) in dose of 1 mg/ml (LD84) induces the particular changes in the thrombocyte vessels system of hemostasis: decrease of aggregatory ability of thrombocytes, increase of thromboxane A2 and prostacyclin activation of lipid...

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Published inNauchnye doklady vysshei shkoly. Biologicheskie nauki no. 7; p. 58
Main Authors Malov, V A, Studennikova, L N, Pak, S G, SAchek, M M, Vinnitskiĭ, L I
Format Journal Article
LanguageRussian
Published Russia (Federation) 1991
Subjects
Animals
Blood Platelets - drug effects
Blood Vessels - drug effects
Cyclooxygenase Inhibitors - therapeutic use
Drug Evaluation, Preclinical
Endotoxins
Free Radicals
Hemostasis - drug effects
Indomethacin - therapeutic use
Lipid Peroxidation - drug effects
Male
Rabbits
Salmonella Infections, Animal - blood
Salmonella Infections, Animal - drug therapy
Salmonella Infections, Animal - etiology
Salmonella typhimurium
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Summary:Injection of Salmonella typhimurium endotoxin to the laboratory animals (rabbits) in dose of 1 mg/ml (LD84) induces the particular changes in the thrombocyte vessels system of hemostasis: decrease of aggregatory ability of thrombocytes, increase of thromboxane A2 and prostacyclin activation of lipid peroxidation process. Use of indomethacin--the cyclooxygenase inhibitor--leads to less progressive alterations of the studied parameters of the thrombocyte vessels hemostasis and lipid peroxidation processes.
ISSN:0470-4606