Evaluation of the therapeutic effect of flumazenil in hepatic encephalopathy using cerebral cartography

We investigated the therapeutic effect of flumanezil on acute and chronic hepatic encephalopathy in a group of cirrhotics; its efficacy was evaluated using clinical data and neurophysiologic examination, e.g. brain mapping. Flumazenil was not found to induce significant changes in the clinical statu...

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Bibliographic Details
Published inRevista espanola de las enfermedades del aparato digestivo Vol. 75; no. 3; p. 277
Main Authors Bello Mimbrera, G, García de León, M, de la Torre Gutiérrez, S, Montero Vázquez, J, Torres Salcines, J, de la Torre Fernández, J M
Format Journal Article
LanguageSpanish
Published Spain 01.03.1989
Subjects
Acute Disease
Aged
Brain Mapping
Chronic Disease
Drug Evaluation
Female
Flumazenil - therapeutic use
Hepatic Encephalopathy - complications
Hepatic Encephalopathy - drug therapy
Hepatic Encephalopathy - physiopathology
Humans
Liver Cirrhosis - complications
Male
Middle Aged
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Summary:We investigated the therapeutic effect of flumanezil on acute and chronic hepatic encephalopathy in a group of cirrhotics; its efficacy was evaluated using clinical data and neurophysiologic examination, e.g. brain mapping. Flumazenil was not found to induce significant changes in the clinical status or in maps of the cerebral activity of patients with chronic encephalopathy. In acute encephalopathy, flumazenil improved clinical status, as was confirmed neurophysiologically by improved cerebral activity on brain mapping.
ISSN:0034-9437