The action of the alkanol ammonium salts of aroxyacetic acids on the thrombocyte aggregation process

Tris(2-hydroxyethyl)ammoniates of ezo-substituted aroxyalkane-carboxylic acids were examined for their effects on in vitro platelet aggregation under the influence of biogenic amines, as well as in lipid peroxidation. Hemocoagulation was evaluated in vivo. The agents tested were demonstrated no be a...

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Bibliographic Details
Published inĖksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 58; no. 3; p. 37
Main Authors Kazimirovskaia, V B, Semenova, N V, Moskvitina, L T, Nepsha, V D, Novikova, N V, Voronkov, M G
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1995
Subjects
Acetates - pharmacology
Adenosine Diphosphate - pharmacology
Animals
Antioxidants - pharmacology
Lipid Peroxidation - drug effects
Luminescent Measurements
Malondialdehyde - blood
Platelet Aggregation - drug effects
Platelet Aggregation Inhibitors - pharmacology
Rabbits
Structure-Activity Relationship
Time Factors
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Summary:Tris(2-hydroxyethyl)ammoniates of ezo-substituted aroxyalkane-carboxylic acids were examined for their effects on in vitro platelet aggregation under the influence of biogenic amines, as well as in lipid peroxidation. Hemocoagulation was evaluated in vivo. The agents tested were demonstrated no be a promising class of platelet aggregation inhibitors. They possess antioxidative effects, by reducing the level of malonic dialdehyde in induced hyperaggregation and the rate of lipid peroxidation. When given to animals, the agents decreased the activity of prothrombin factors.
ISSN:0869-2092